hs-CRP is one of the most accessible inflammation markers, but also one of the easiest to misread. A single high value during a cold doesn't tell you much. A stable, repeatedly elevated value does.
What hs-CRP measures
C-reactive protein is an acute-phase protein produced by the liver in response to inflammation. The "high-sensitivity" assay detects low-level, chronic inflammation in the range relevant to cardiovascular risk, not just acute illness.
What the numbers mean
A commonly cited framework: under 1 mg/L is considered lower risk, 1–3 mg/L is average, and above 3 mg/L is higher risk. Values above 10 mg/L usually reflect an acute process (infection, injury, flare) and are not useful for baseline risk estimation until they settle.
Why trend matters more than any single reading
hs-CRP swings with colds, dental problems, poor sleep, intense exercise, and recent flares of any chronic condition. A one-off reading means less than two or three readings drawn when you're feeling well, spaced weeks apart. If those all sit elevated, the signal is real.
What can move it
Body fat, poor sleep, smoking, periodontal disease, and autoimmune activity push it up. Regular exercise, weight loss, and treatment of an underlying inflammatory condition tend to bring it down. Some lipid medications modestly lower it as a side effect. Acute infections spike it and aren't a reason to worry about the number.
How VisitRecall tracks it
Timeline every reading alongside what was going on when it was drawn — so a cold doesn't get mistaken for a trend. See lab tracking and the longevity hub.
FAQ
Is one high reading a problem?
Not by itself. Repeat when you're feeling well and haven't exercised intensely in 24–48 hours.
Does it tell me what's causing inflammation?
No. It's a general signal. Identifying the source takes more targeted workup with your clinician.
How often should I retest?
If you're asymptomatic and have a baseline, many people retest annually or when something changes. Your doctor may suggest more often.
